منابع مشابه
Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats.
The aim of this study was to investigate the possible role of N-methyl-D-aspartate (NMDA)-receptor overactivity in two different experimental rat models of encephalopathy: subacute encephalopathy caused by severe hyperammonemia in portacaval-shunted rats (AI-PCS rats) and acute hepatic encephalopathy caused by complete liver ischemia (LIS rats). The effect of the noncompetitive NMDA-receptor an...
متن کاملFecal transplant to mitigate hyperammonemia and hepatic encephalopathy in animal models.
The paper by Shen, et al. reports on efforts to engineer the gut microbiota to treat hyperammonemia by decreasing the levels of urease positive gut bacteria.1 After treatment of mice with oral antibiotics and PEG to deplete indigenous bacteria, mice were inoculated with a consortium of 8 bacteria with low urease gene content. This new gut microbiota was relatively stable for up to 120 days. The...
متن کاملHyperammonemia Is Associated with Increasing Severity of Both Liver Cirrhosis and Hepatic Encephalopathy
Background. Hyperammonemia resulting from chronic liver disease (CLD) can potentially challenge and damage any organ system of the body, particularly the brain. However, there is still some controversy regarding the diagnostic or prognostic values of serum ammonia in patients with over hepatic encephalopathy, especially in the setting of acute-on-chronic or chronic liver failure. Moreover, the ...
متن کاملHepatic encephalopathy
Hepatic encephalopathy (HE) is a reversible syndrome of impaired brain function occurring in patients with advanced liver diseases. The precise pathophysiology of HE is still under discussion; the leading hypothesis focus on the role of neurotoxins, impaired neurotransmission due to metabolic changes in liver failure, changes in brain energy metabolism, systemic inflammatory response and altera...
متن کاملHepatic Encephalopathy
The liver is the most important organ for the well-functioning of other organs because of its vital role in nutrition, metabolism and secretion. Any disturbance in normal homeostasis of liver as it happens in acute liver failure (ALF) and chronic liver disease (cirrhosis) will lead to extra hepatic manifestations of liver disease, among them one is encephalopathy. And this encephalopathy caused...
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ژورنال
عنوان ژورنال: Journal of Clinical and Experimental Hepatology
سال: 2018
ISSN: 0973-6883
DOI: 10.1016/j.jceh.2018.06.007